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In the last ten years, Kenya has embraced nuclear medicine for both diagnostics and therapy in various health facilities. This has been part of the National Cancer Control Strategy. The number of nuclear medicine centers has increased from 3 in 2012 to 8 in 2022. Two of the facilities operate cyclotrons for the production of the F-18. The practice leads to the generation of low and medium levels of radioactive waste. This paper intends to share with the international community the challenges related to the generation and management of waste, including regulatory challenges and steps taken by the industry to address them.