The mission of the U.S. Department of Energy’s National Nuclear Security Administration (DOE/NNSA) Office of Nuclear Smuggling Detection and Deterrence (NSDD) is to strengthen the capabilities of partner countries to detect, disrupt, and investigate the smuggling of nuclear and radioactive material. NSDD works with over 80 national and international partners to achieve its mission. The ongoing COVID-19 pandemic has adversely impacted the ability to carry out in-person engagements and interactions. To address this challenge, former in-person engagements such as Scenario-Based Policy Discussions and scoping visits for building and maintaining partnerships were modified to virtual engagements to continue building partner countries’ capabilities to respond to nuclear security events. These unique virtual engagements focus on developing or exercising collaboration between different stakeholders in a partner country to encourage information sharing and to clarify the role of each stakeholder in supporting investigations.