International Conference on Applications of Radiation Science and Technology

Monodispersed Polypyrrole Nanoparticles Prepared via Water Padiolysis and their Photothermal Therapy on Cancer Cells

27 Apr 2017, 14:15

2h

IAEA Board Room B/M1 (IAEA Headquarters)

Poster RADIATION SYNTHESIS AND MODIFICATION OF MATERIALS P-A2

Speaker

Mr Xue Wu GE (Department of Polymer Science and Engineering, University of Science and Technology of China, China)

Description

The combination of NIR photothermal therapy and chemotherapy is considered as the promising technique for the future cancer therapy.[1] The key point for this technique is the design and synthesis of photothermal agents with high-efficiency phtotothermal effect and high chemical drug loading capacity.[2] Herein, submicron-sized raspberry-like hollow-structured polypyrrole microspheres (H-PPy) were facily prepared through the in-situ polymerization of pyrrole on monodispersed polystyrene (PS) template microspheres with a diameter of 220 nm, followed by the chemical etching of the PS templates. The prepared H-PPy microspheres show rapid and remarkable photothermal effect in water under the irradiation of NIR laser (808 nm) only for 5 min. Further, a model small molecular drug, (S)-(+)-camptothecin (CPT), were loaded into the void core by a simple dispersion-permeation process through the micro-pores on the raspberry-like PPy shell, with a load capacity of 0.14 mg/(mg H-PPy). The MTT assay and the in vitro NIR-laser triggered release behavior indicated that the pure H-PPy microspheres have good biosafety, but the release of loaded CPT in H-PPy microsphere can be achieved with remarkable spatial/temporal resolution after NIR laser irradiation, which results in the excellent synergistic effect of photothermal and chemical ablation on HeLa cells, as proved by the fluorescence microscopy. This work provides a convenient synthesis of a promising cancer therapy agent with high drug-loading capacity and efficient NIR light photothermal effect, which can perfectly achieve the synergistic NIR photothermal therapy and chemotherapy of PPy microspheres. [1] K. Dong, Z. Liu, Z. H. Li, J. S. Ren and X. G. Qu, Adv. Mater., 2013, 25, 4452-4458. [2] J. P. Yang, D. K. Shen, L. Zhou, W. Li, X. M. Li, C. Yao, R. Wang, A. M. El-Toni, F. Zhang and D. Y. Zhao, Chem. Mater., 2013, 25, 3030-3037.