International Conference on Applications of Radiation Science and Technology

Molecular Design and Synthesis of Different Polymer-Based Nanoparticles as Nanocarriers Using Irradiation Techniques

27 Apr 2017, 17:10

20m

IAEA Board Room B/M1

Oral RADIATION SYNTHESIS AND MODIFICATION OF MATERIALS A13

Speaker

Ms Wanvimol PASANPHAN (Department of Materials Science, Faculty of Science, Kasetsart University, Thailand)

Description

Significant progress has been made during the past decade in preparing
polymer-based nanoparticles (NPs) as nanocarriers for a wide range of applications. One of the next
critical challenges is developing a green, robust and versatile method using irradiation techniques which allows
the synthesis of different polymer nanoparticles into functional structures tailored for each specific
purpose. In this work, we proposes the molecular design and irradiation-assisted synthesis for the creation of polymer-based nanostructures, i.e., amphiphilic polymer core-shell NPs, inter-polymer complex NPs, polymer-capped metal NPs and hydrid NPs to be applied as nanocarrier for drug delivery, agrochemical entrapment, paint and coating additives. According to the different molecular structures, radiation-induced degradation, grafting and polymerization were carried out in particular water-based system at room temperature. Gamma rays and electron beam irradiation doses ranging from 5 to 100 kGy were selected and controlled to achieve nanocale structure with the size of 10-300 nm. The amphiphilic core-shell water-soluble chitosan NPs (~120 nm) could encapsulate Berberine and Paclitaxel anticancer drugs with the drug content of 37% (w/w). Chitosan-polyacrylic acid interpolymer complex NPs (54 nm) efficiently entrap 20% (w/w) ammonium nitrate fertilizer and exhibit pH responsive function. Gold nanoparticle (5-50 nm) was successfully green synthesized in the water-soluble chitosan (WSCS) produced from radiation-induced degradation. In addition, electron beam can also accelerate the production of AuNPs in WSCS. The polymer brush shells were grafted onto silica NPs and silver NPs (5 nm) were then constructed on the polymer brush-grafted-silica NPs (98 nm). The obtained hybrid NPs effectively inhibited the growth of building fungi, i.e., *Spergillus Niger* and *Syncephalastrum Racemosum*. All types of polymer-based nanoparticles with different functions were successfully designed and prepared using irradiation techniques.