Description
Session for the presentation of Oral presentations on Radiobiology
NTCP and estimation of secondary cancer risk in Modulated Arc Therapy for prostate carcinoma using in-house software.
1A.Boughalia, 2M.Fellah, 3 Ben Amirouche, 3A.Nekaa
1Medical Physics Department, Nuclear Research of Algiers, Algeria
a.boughalia@crna.dz
2Physics Faculty, Houari Boumedienne University Bab Ezzouar Algiers, Algeria
Fellahm1@yahoo.fr
3Radiotherapy Oncology Department,...
Introduction
Neutron Capture Enhanced Particle Therapy (NCEPT) is a novel adjunct to proton and heavy ion therapy, which enhances the radiation dose delivered to a tumour relative to surrounding healthy tissue by capturing thermal neutrons produced during ion irradiation. NCEPT utilises $^{10}$B and $^{157}$Gd-enriched tumour-specific neutron capture agents presently approved or in...
Telomeres play a critical and opposing role in the process of carcinogenesis, serving as an obstacle e during early stages of cell transformation and later a cancer hallmark for unlimited cell proliferation. . Reactivation of telomerase is essential for telomere maintenance in human cancer cells ensuring indefinite proliferation. Targeting telomere homeostasis has become one of the promising...
The question of delivery of concomitant boost – additional small dose about 0.3 Gy locally to the tumor in the same fraction of external irradiation - is still under consideration. It was discussed in the literature from time to time. Especially it concerns the irradiation of rectal cancer. An obvious obstacle to this regime of irradiation is the additional time spent on an additional planning...
Salivary α-amylase, an enzyme present in the oral cavity, is responsible for the breakdown of starch to smaller carbohydrate molecules. Xerostomia, or dry mouth, is a known effect on patients undergoing radiotherapy. Salivary α-amylase was used in this study to assess the severity of xerostomia on thirty (30) Head and Neck Squamous Cell Carcinoma (HNSCC) patients undergoing radiotherapy in...
Introduction
The need for hospitals to be prepared for the act of clinical mistreatment, radiation accidents and radiological terrorism is of high priority. In order to quantify the amount of dose received during any radiation accidents, a well-developed and reliable method of dosimetry is required. At present, physical dosimeters are well established to quantify radiation doses. Whereas,...
Introduction
Despite technological advances in cancer treatment especially in radiotherapy, cancer cells radioresistance still leave a problem for radiation oncologist. In line with that, many efforts are being made in to increase therapeutic ratio, in order to reduce toxicity to surrounding healthy organ and increasing local/locoregional control in tumor. One among the most popular...
Introduction
The high-linear energy transfer (High-LET) radiation has shown to increase biological effects compared to Low-LET radiation. High-LET radiation deposits their energy locally and densely throughout their path, which allows more conformal dose delivery to the targeted cells. It is reported that biological damage from High-LET radiation is greater than the Low-LET radiation....
Introduction
Radiotherapy is an important modality of therapy in cancer treatment. Despite of advances in technology and cancer genomics, treatment of cancer is still a big challenge, and the mutation signatures of radioresistant tumors have not yet been fully elucidated. Radiation therapy technique is evolving over time, as increasing of radiation conformity will increase therapeutic ratio,...
