Prostate-specific membrane antigen is a prominent imaging biomarker in nuclear medicine. With Gallium-68 (68Ga) opportunely available to hospital radiopharmacies we recently developed a PSMA11 single kit vial radiolabeling solution which is now routinely used in the Steve Biko Academic hospital in Pretoria, South Africa. The most widely used therapeutic pendant for 68Ga is 177Lu but recent...
Background: 188ReN-DEDC/lipiodol(DEDC – diethyldithiocarbamate) is a clinically established agent for the therapy of unresectable hepatocellular carcinoma (HCC). Original two-vial method for the preparation of 188ReN-DEDC/lipiodol involved compulsory addition of stipulated amount of glacial acetic acid (GAA), which was cumbersome in a busy radiopharmacy. Moreover, an error in glacial...
Introduction: Hepatic radioembolization is a minimally invasive procedure involving intrarterial administration of radioembolic microparticles for the treatment of liver tumours. A biocompatible polystyrene (PS) microparticles containing Samarium-153 (153Sm) were developed for hepatic radioembolization therapy. The incorporation of 153Sm that possessed both diagnostic gamma energy and...
Background:
The effectiveness of Y-90-DOTATATE as a therapeutic radiopharmaceutical for Peptide Receptor Radionuclide Therapy(PRRT) in treatment of large volume neuroendocrine lesions is well established. The high energy of β- particle emission(Emax: 2.28MeV) is suitable for treatment of neuroendocrine lesion with diameter of 5cm and more. The challenges involved in the formulation of...
