A novel therapeutic phthalimide derivative for cancer: Synthesis, radioiodination and biological evaluation
M. A. Motaleb 1, I. Y. Abdel-Ghaney 1, H. M. Abdel-Bary 2 , H. A. Shamsel-Din 1
1 Labeled Compounds Department, Hot Labs Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt
2 Faculty of Science, Menoufia University, Cairo, Egypt
Abstract
Objective of the study: Developing...
Cancer is one of the leading causes of death in the world, including Indonesia. By 2030, it is estimated that cancer sufferers reach 26 million people and 17 million dies from cancer, with a faster increase in developing countries. The application of nuclear techniques in nuclear medicine plays an important role in diagnosing cancer, measuring therapy responses, and identify an optimal...
Neuromedin N is a hexapeptide that shares the 4 amino acid Pro-Tyr-Ile-Leu homology with neurotensin and exhibits neurotensin-like effects in malignant glioma cells. Neuromedin B is a bombesin-like peptide which specifically binds to BN receptors widely expressed in central nervous system and in peripheral tissue and organs. This study was aimed to select and...
Background:
Prostate cancer is the second most prevalent cancer worldwide. 177Lu-PSMA-617 has emerged as a useful therapeutic modality in the management of metastatic castration-resistant prostate cancer. The present work describes a ready-to-use 177Lu-PSMA-617 injectable formulation of the therapeutic radiopharmaceutical, produced using medium specific activity 177Lu (> 15 Ci/mg), and...
Background
The symptomatic treatment of skeletal pain due to metastases is complex. Especially in patients with multiple skeletal lesions and osteoblastic lesions on skeletal scintigraphy, systemic radiotherapy with radionuclides linked to a bone-seeking agent is preferred because of its efficacy, low cost, and comparatively low toxicity. Various radiopharmaceuticals available for this...
Background/Objective; Currently sentinel lymph node (SLN) dissection is an important procedure alongside to the tumour removal surgery especially for breast cancer. In general SLN can be localised with blue dye or radiocolloid. In Nuclear Medicine, several types of radiocolloid have been utilised such as 99mTc sulfur colloid, 99mTc nanocolloid including 99mTc dextran. One of the critical...
There are no complaints and symptoms in the early-stage of cancer which causes the patient is not aware of the presence cancer in their body. The spread of cancer cells could be prevented if known earlier. One of the early methods of cancer detection which is being developed currently is technique of nuclear medicine using radiopharmaceutical. A Radiopharmaceutical has two components: a...
Background
For years, bisphosphonates (BP) were known for its role in reducing the risk of skeletal related event in patients with bone metastases by accumulating and inhibiting the osteoclastic activity. Hence, since the emergence of germanium-68/gallium-68 generator for positron emission tomography (PET) imaging, developments in gallium-68 labeled BP for bone imaging have been looked into....
Background/goal/objective of the study
This study aimed to synthesize and characterize of N-(2,4,6-trimethylphenylcarbamoylmethyl)iminodiacetic acid (TMIDA) and then radiolabel it with technetium-99m by direct technique using sodium didithionite as reducing agent. The labeling parameters including TMIDA concentration, sodium didithionite concentration, pH of the reaction mixture, reaction...
Background/Goal/Objective of the study; Theranostic concept was coined first by John Funkhouser in the last two decades utilizing the combination of a high specific drug that targets diagnostic and therapeutic tools for a specific disease. As a part of personalized medicine, theranostics was practically established in oncology as well as applied to nuclear medicine by labelled gamma emitter...
