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Description
99mTc -tetrofosmin is a lipophilic cationic agent (diphosphine group) used for imaging myocardial perfusion at stress and at rest. The myocardial uptake of technetium 99mTc -tetrofosmin appears to occur by a passive diffusion process however, the uptake and retention curve models of technetium 99mTc -tetrofosmin by myocardial tissue are not well established. Particularly early images for myocardial perfusion imaging and stability of 99mTc -tetrofosmin are not well defined. 15 preparations of 99mTc -tetrofosmin and 40 patients have been used to study the different parameters part of the process of labeling in order to study the stability of 99mTc -tetrofosmin and its early uptake at 5 minutes by myocardial muscle. Parameters which have been studied were the PH, temperature of storage, time of agitation and the way of intravenous injection. Radiochromatography was performed at different times during 6 hours and early myocardial uptake was estimated by the ration heart/mediastinum uptake. Early results confirm that constant agitation and storage temperature are influencing the in vitro stability of 99mTc -tetrofosmin meanwhile clinical indications and the PH of the injected solution of 99mTc –tetrofosmin are influencing the early uptake of 99mTc –tetrofosmin by the myocardium.
